I've been hammering for this feature ever since I joined the EA Sports Game Changer program as I feel that it is another important aspect of NCAA Football that we were simply missing. You guys who love the no-huddle and up-tempo offenses are going to be challenged with managing substitutions or risk getting the ball to a running back or wide receiver and him not having any gas left in the tank to take it anywhere up field. This will also force people to actually look at your substitution sliders in your coaching preferences.
This will also effect some special team decisions. Not that it was a good idea before, but utilizing your star skill players for punt and kick returners will ultimately reduce their effectiveness as the workhorses for your offensive attack. Additionally, a guy with 99 SPD 99 ACL and 99 AGI may not be the best option as a kick returner if his stamina is only a 62. Sure, he breaks the field open more often than anyone else on your team, but you won't think as highly of him when he gets sucked up from behind every time as he starts to fatigue. Conversely, players with lower speeds but higher stamina ratings will be rewarded for sticking with a play and taking good angles as their efforts could end up paying off in the form of a touchdown saving tackle.