If the new slider system is working as it's supposed to... and that's a big "IF." We would still be able to tweak the game somewhat. I'm thinking along the same lines as Nza. Of course, none of us will know for sure until we have the game in hand and start tweaking away to see which slider actual work.
According to Ian, the sliders are really increased/decreased points to certain player attributes. Therefore, using the old sliders raise/lower CPU RUN ABILITY is really raising/lowering the CPU's JUKE, SPEED, BRK TKL, etc. Now since there is no CPU RUN ABI to raise/lower, we will have to raise/lower the HUM RUN DEF to compensate... so there are still ways to tweak the game... if it all works as advertised.