I don't believe so. I think that the sliders work the same on all levels. I just tested the User QB Accuracy slider that I mentioned earlier on Varsity and it still works the same.
I dropped down to AA, only for about half a quarter though, and did get some better pressure but it's hard to say if it was just the drop. I then spent two and a half quarters on Varsity while swapping the CPU RB Ability back and forth every defensive series and I'm not really seeing a difference. I've been getting pretty much equal pressure on both. But then again, maybe I just suck at pass rushing.
BTW, when I was Heisman earlier, I was playing Western Kentucky @ Georgia(Me) and I wasn't getting any pressure off of that slider. So I'm really hoping that it's not that slider because if it is, then I truly do suck at pass rushing. I've moved to a more even Marshall @ UCF now though.
And, hopefully I didn't miss this already, but what system is everyone playing on? Could it be that the sliders are mapped differently between the two? Personally, I'm on the PS3.